Principal Scientist, Chemistry

Date Posted: June. 3, 2021
Number of the position: 0-1

Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at FIMECS. Join us as a Principal Scientist, Chemistry in our Shonan site.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Principal Scientist, Medicinal chemistry working on the Chemistry department, you will be empowered to lead medicinal chemistry team including external CRO members as a manager, and a typical day will include:

We are searching for a Principal Scientist to join the Chemistry group within the Research organization. We are seeking an enthusiastic, highly motivated scientist to lead for expanding our platform technology and pipeline of early clinical development molecules. The successful applicant should be capable not only of design and synthesis of bioactive molecules, but also manage chemistry members including external CROs. Strong medicinal chemistry experience ideally oncology research area is required for this position.


  • Design, synthesize, and characterize biologically active small molecules with suitable drug-like properties
  • Collaborate with a broad group of scientists within the Company and with external partners (Pharma, Academia, CRO, etc.) as a key contributor
  • Maintain a broad awareness of the scientific and technological landscapes of organic synthesis, medicinal chemistry and drug discovery
  • Supervise the group/team members


  • PhD. or its equivalent in organic chemistry, medicinal chemistry, or related discipline, with 2-5 years of focused training or work experience in one or more of protein degraders, bRo5 molecules, combinatorial chemistry, chemical biology, peptide chemistry, tracer synthesis or oncology drug discovery
  • Scientific expertise in organic synthesis, including awareness and understanding of current organic chemistry trends
  • High level of creativity and productivity with strong problem-solving skills and the ability to champion chemistry efforts towards new directions to achieve project milestones
  • Oral and written Japanese skills (native level) to discuss with team members, service venders and others and prepare the intellectual patents and presentations
  • Oral and written Japanese/English skills to close communicate with abroad Partners, such as Pharma, Academia and CROs
  • Outstanding oral and written communication skills and the ability to present rationale, key data, issues and accomplishments to project teams
  • Ability to think strategically to improve current processes within the chemistry department


  • Experience of project lead
  • Experience of later stage research
  • Knowledge for molecular biology, biophysics and in vitro ADME-tox study
  • Knowledge of process chemistry, CMC and toxicological studies
  • Class-A Hazardous Materials Engineer license in Japan


  • Health & Wellness programs
  • Generous time off for vacation
  • Stock option program (possibility to be granted after 2022)

26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-0012, Japan



Full time by discretionary labor system

7.6-10.0M JPY per year depends on experiences, capabilities, skills, and DESIRABLE REQUIREMENTS






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